Hypogonadal symptoms in young men are associated with a serum total testosterone threshold of 400 ng/dL

Jason Scovell et al. BJU Int. 2015 Jul.


Investigate the association between hypogonadism (low testosterone) and serum total testosterone (TT) levels in young men; < 400 ng/dL. 


Probability of hypogonadal symptoms increase at a serum TT level of 400 ng/dL. A cluster of symptoms were the most strongly associated with serum TT levels of < 400 ng/dL which included the following: (Psychological) Decrease energy/increase fatigue and sadness/depression; (Physical) Decrease strength and endurance, decrease ability to play sports, and deterioration in work performance. Lack of energy predicted a TT level of < 400 ng/dL under multivariable analysis. 


Low testosterone symptoms in men < 40 years can be associated with a TT level < 400 ng/dL. Lack of energy appears to be the most important symptom that predicts a TT level of < 400 ng/dL.


Low testosterone (hypogonadism) can present with multiple symptoms and be easily missed. If you are a male and under the age of 40 and are experiencing any of these symptoms: Increase fatigue, Sadness/depression, decrease general strength, and deterioration in work performance have your testosterone level evaluated.

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author avatar
Adam Weldzius, NP